23rd April » The Bayerische Reinheitsgebot (regarding the ingredients of beer) is signed in Ingolstadt.
8th May » Trần Cảo Rebellion: A group of imperial guards, led by Trịnh Duy Sản, murdered Emperor Lê Tương Dực and fled, leaving the capital Hanoi named Thăng Long undefended.
24th August » The Ottoman Empire under Selim I defeats the Mamluk Sultanate (Cairo) e.g Mamluk Sultanate and captures present-day Syria at the Battle of Marj Dabiq.
28th October » Battle of Yaunis Khan: Military of the Ottoman Empire called Turkish forces under the Grand Vizier Sinan Pasha defeat the Mameluks near Gaza City named Gaza.
Famous Birthdays in 1516
1st January » Margaret Leijonhufvud, Swedish wife of Gustav I of Sweden (d. 1551)