22nd January » The Ottoman Empire under Selim I defeats the Mamluk Sultanate (Cairo) or Mamluk Sultanate and captures present-day Egypt at the Battle of Ridaniya.
15th August » Seven Portuguese armed Watercraft vessels led by Fernão Pires de Andrade meet China Chinese officials at the Pearl River Delta Pearl River estuary.
31st October » Protestant Reformation: Martin Luther posts his 95 theses on the door of the Castle Church in Wittenberg.