4th March » Hernán Cortés arrives in Mexico in search of the Aztec civilization and its wealth.
22nd April » Spanish conquistador Hernán Cortés establishes a settlement at Veracruz, Veracruz called Veracruz, Mexico.
28th June » Charles V, Holy Roman Emperor named Charles V is elected Emperor of the Holy Roman Empire.
10th July » Zhu Chenhao declares the Ming Dynasty emperor Zhengde Emperor known as Zhengde a usurper, beginning the Prince of Ning rebellion, and leads his army north in an attempt to capture Nanjing.
20th August » Philosopher and general Wang Yangming defeats Zhu Chenhao, ending the Prince of Ning rebellion against the reign of the Ming Dynasty emperor Zhengde Emperor or Zhengde.
20th September » Ferdinand Magellan sets sail from Sanlúcar de Barrameda with about 270 men on his expedition to circumnavigate the globe.
8th November » Hernán Cortés enters Tenochtitlán and Aztec ruler Moctezuma II known as Moctezuma welcomes him with a great celebration.