27th April » Combined forces of Habsburg Spain Spain and the Papal States defeat a Kingdom of France French and Republic of Venice Venetian army at the Battle of Bicocca.
26th June » Ottomans begin the second Siege of Rhodes (1522) called Siege of Rhodes.
20th December » Siege of Rhodes (1522) Siege of Rhodes: Suleiman the Magnificent accepts the surrender of the surviving Knights Hospitaller Knights of Rhodes, who are allowed to evacuate. They eventually settle on Malta and become known as the Knights Hospitaller Knights
Famous Birthdays in 1522
2nd February » Lodovico Ferrari, Italian mathematician (d. 1565)
28th March » Albert Alcibiades, Margrave of Brandenburg-Kulmbach (d. 1557)