6th January » The Committee of Inquiry on the South Sea Company called South Sea Bubble publishes its findings.
24th March » Johann Sebastian Bach dedicated six concertos to Margrave Christian Ludwig of Brandenburg-Schwedt named Christian Ludwig, margrave of Brandenburg-Schwedt, now commonly called the Brandenburg concertos, BWV 1046–1051.
4th April » Sir Robert Walpole takes office as the first Prime Minister of the United Kingdom under George I of Great Britain called King George I.
26th April » 1721 Tabriz earthquake known as A massive earthquake devastates the Iranian city of Tabriz.
Famous Birthdays in 1721
12th January » Duke Ferdinand of Brunswick, Prussian field marshal (d. 1792)
19th January » Jean-Philippe Baratier, German scholar (d. 1740)
21st January » James Murray (Quebec governor) named James Murray, Scottish general and politician, Governor of Minorca (d. 1794)
3rd February » Friedrich Wilhelm von Seydlitz, Prussian general (d. 1773)
6th February » Christian Heinrich Heineken, German scholar (d. 1725)
13th February » John Reid (British Army officer) known as John Reid, Scottish general (d. 1807)
21st February » John McKinly, American physician (d. 1796)
19th March » Tobias Smollett, Scottish author (d. 1771)
1st April » Pieter Hellendaal, Dutch-English organist, violinist, and composer (d. 1799)
11th April » David Zeisberger, Czech-American clergyman and missionary (d. 1808)
15th April » Prince William, Duke of Cumberland (d. 1765)
19th April » Roger Sherman, American lawyer and politician (d. 1793)
9th July » Johann Nikolaus Götz, German poet (d. 1781)
14th July » John Douglas (bishop of Salisbury) e.g John Douglas, Scottish bishop (d. 1807)
4th August » Granville Leveson-Gower, 1st Marquess of Stafford, English politician, Lord President of the Council (d. 1803)
31st August » George Hervey, 2nd Earl of Bristol, English politician, Lord Lieutenant of Ireland (d. 1775)
9th September » Fredrik Henrik af Chapman, Swedish admiral and shipbuilder (d. 1808)
14th September » Eliphalet Dyer, American colonel, lawyer, and politician (d. 1807)
19th October » Joseph de Guignes, French orientalist and sinologist (d. 1800)
9th November » Mark Akenside, English physician and poet (d. 1770)
22nd November » Joseph Frederick Wallet DesBarres, Swiss-Canadian cartographer and politician, List of lieutenant governors of Nova Scotia or Lieutenant Governor of Nova Scotia (d. 1824)
6th December » James Elphinston, Scottish philologist and educator (d. 1809)
6th December » Guillaume-Chrétien de Lamoignon de Malesherbes, French minister and politician (d. 1794)
9th December » Peter Pelham (composer) named Peter Pelham, English-American organist and composer (d. 1805)
27th December » François Hemsterhuis, Dutch philosopher and author (d. 1790)
29th December » Madame de Pompadour, French mistress of Louis XV of France (d. 1764)
Famous Deaths in History for 1721
16th February » James Craggs the Younger, English politician (b. 1686)
24th February » John Sheffield, 1st Duke of Buckingham and Normanby, English poet and politician (b. 1648)
16th March » James Craggs the Elder, English politician (b. 1657)
14th April » Michel Chamillart, French politician (b. 1652)
8th July » Elihu Yale, American-English merchant and philanthropist (b. 1649)
18th July » Jean-Antoine Watteau, French painter (b. 1684)
3rd August » Grinling Gibbons, Dutch-English sculptor and woodcarver (b. 1648)
13th August » Jacques Lelong, French author (b. 1665)
8th September » Michael Brokoff, Czech sculptor (b. 1686)
11th September » Rudolf Jakob Camerarius, German botanist and physician (b. 1665)
18th September » Matthew Prior, English poet, politician, and diplomat, List of ambassadors of the United Kingdom to France known as British Ambassador to France (b. 1664)